منابع مشابه
Tutorial in Molecular and Cellular Biology Cell Calcium, Oncogenes, and Hypertrophy
The cellular mechanisms of cardiac hypertrophy remain unclear despite tantalizing clues gleaned from a variety of experimental approaches. Here we examine the hypothesis that an increase in cytosolic free Ca concentration ([Ca],) triggers the expression of protooncogenes, which in turn direct the characteristic increase in protein synthesis. New results from perfused ferret hearts are presented...
متن کاملOncogenes and cell proliferation. Web alert.
Addresses *:~National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, Room 8N-805, Bethesda, Maryland 20894, USA tNational Human Genome Research Institute, National Institutes of Health, Building 49, Room 2B75, Bethesda, Maryland 20892-4431, USA *e-mail: [email protected] te-maih [email protected] Se-mail: makalowski@...
متن کاملOncogenes and anti-oncogenes in tumorigenesis.
Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences. Their contribution to the tumorigenic phen...
متن کاملHyperglycemia inhibits capacitative calcium entry and hypertrophy in neonatal cardiomyocytes.
Hyperglycemia alters cardiac function and often leads to diabetic cardiomyopathy as cardiomyocyte apoptosis causes a hypertrophied heart to deteriorate to dilation and failure. Paradoxically, many short-term animal models of hyperglycemia protect against ischemia-induced damage, including apoptosis, by limiting Ca(2+) overload. We have determined that, like nonexcitable cells, both neonatal and...
متن کاملCalcium, calpains, and cardiac hypertrophy: a new link.
Letters to the Editor will be published, if suitable, as space permits. They should not exceed 1000 words (typed double-spaced) in length and may be subject to editing or abridgment.ernier et al assessed the effects of calpain inhibition on angio-tensin (Ang) II–induced cardiovascular remodeling. 1 These authors used transgenic mice expressing high levels of calpastatin to inhibit Ang II– depen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 1990
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.15.6.652